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TOKYO, Oct 27 (Reuters) - Takeda Pharmaceutical Co raised its full-year profit forecast on Thursday as the falling yen boosted the value of overseas sales and opened up opportunities for Japan's biggest drugmaker to buy in-development treatments.

The company, which makes more than 80% of its sales outside Japan, said it expected operating profit to reach 530 billion yen ($3.65 billion) in the year through March 2023, versus earlier guidance of 520 billion yen, and 461 billion earned the previous year.

That is still lower than the consensus forecast of 597 billion yen in a Refinitiv survey of 16 analysts.

"There is no real scenario where further depreciation would be a downside for us," chief executive Christophe Weber told Reuters after the release of mid-year results, referring to the weaker yen.

Takeda is reaping benefits from the $59-billion purchase of Shire Plc in 2019 that expanded its footprint in North America, but which was criticised as too costly by some analysts and shareholders.

Almost half the drugmaker's sales are now in North America, generating proceeds that grow in value when repatriated as the yen has depreciated by 22% this year against the dollar.

The Shire acquisition saddled Takeda with debt, prompting it to sell off non-core assets. As it continues to reduce borrowings, and aided by the currency tailwind, Takeda is looking to buy drugs in late-stage development to bolster its pipeline, Weber said.

The company is targeting assets in its focus areas of oncology, neuroscience, rare diseases, and gastrointestinal ailments, he said.

"It is also important to enrich our pipeline, because you're not always successful," Weber said.

This month, European regulators gave Takeda a positive opinion on its dengue fever vaccine, paving the way for approvals in numerous countries where the disease is endemic.

Indonesia became the first country to approve the vaccine in August.

It was a sorely needed win after some failures in Takeda's drug pipeline, which will be key for growth after franchise products such as Vyvanse and Entyvio lose patent protection.

For the six months through Sept. 30, operating profit slid 26% to 255 billion yen, reflecting the absence of a one-time gain, the company said.

Takeda netted 131.4 billion yen last year from the sale of its diabetes assets to refocus on core businesses after the Shire purchase.

The profit forecast revision was based on projections of the yen trading at 132 to the dollar, and 138 against the euro, much stronger than prevailing levels.

If Japan's currency maintains its current levels through the year, there would be further upside to earnings, chief financial officer Costa Saroukos said.

Takeda's shares have gained 21% in 2022, versus a drop of 4.7% in the benchmark Nikkei average. ($1=145.2900 yen) (Reporting by Rocky Swift; Editing by Clarence Fernandez)

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