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Liraglutide is a daily injectable medication that mimics endogenous GLP-1, which is produced in the gut and signals the brain to decrease hunger and create a feeling of fullness with smaller meals. Because obesity is a chronic disease, obesity medications should be used long term in combination with a healthy diet and exercise. Wegovy is a brand name for the obesity treatment version of semaglutide, a GLP-1 receptor agonist. For each individual case, the doctor and patient should discuss the patient’s current health issues, other medications, and family medical history. In 2021, attention to obesity medications exploded in popularity and media attention with the approval of semaglutide for obesity treatment under the brand name Wegovy. NIDDK conducts and supports clinical trials in many diseases and conditions, including overweight and obesity. Researchers are working to identify safer and more effective medications to help people who are overweight or have obesity lose weight and maintain a healthy weight for a long time.
The top obesity medications (OMs) at that time were phentermine, marketed as Adipex-P, and orlistat, marketed as Xenical and Alli. Before 2012, there were few weight loss medications approved by the FDA. Always talk with your health care provider before you participate in a clinical study. You can view a filtered list of clinical studies on prescription medications to treat overweight and obesity that are federally funded, open, and recruiting at ClinicalTrials.gov. When you volunteer to take part in a clinical study, you help doctors and researchers learn more about disease and improve health care for people in the future. Clinical trials—and other types of clinical studies—are part of medical research and involve people like you. Side effects and other reactions to weight management medications are possible.10 For more information, visit the FDA drug database, DRUGS@FDA.
Dosing recommendations begin with a daily dose of one 8/90 mg tablet and gradually increase on a weekly basis to a maximum of two tablets twice a day. Naltrexone-bupropion combines an opioid receptor antagonist with an antidepressant to affect the pleasure-reward areas of the brain and thereby decrease cravings and appetite. If more than 5% weight loss is not achieved after 12 weeks of the maximum dose, the weight loss pill should be gradually discontinued. Topiramate, long used for seizure disorders and chronic migraine headache, was approved for obesity treatment in an extended-release combination with phentermine in 2012. It is FDA approved for short-term use but is widely accepted as a long-term option for obesity treatment among obesity medicine prescribers.
In 2025, semaglutide became the first oral GLP-1 receptor agonist to be approved for obesity treatment. Obesity medication may also impact the reward systems in the brain to reduce cravings and lessen food noise. They work primarily by modifying neurohormonal pathways in the brain. These commonly used medications for obesity decrease appetite, improve satiety, and support metabolic health. This surpasses the weight loss seen with semaglutide (Wegovy), which showed 14.9% average loss in the pivotal STEP 1 trial over a similar timeframe.
Ask your health care professional about lifestyle treatment programs for weight management that will work for you. Studies show that weight management medications work best when combined with a lifestyle program. Medications don’t replace physical activity or healthy eating habits as a way to lose weight. If you are overweight or have obesity, you might be able to lose weight with a lifestyle program that changes your behaviors and improves your eating and physical activity habits.
It’s important to talk to your healthcare provider first if you’re thinking of taking OTC appetite suppressants or supplements. Some appetite suppressants can interact with medications, including antidepressants and anti-anxiety drugs (anxiolytics). Short-term prescription appetite suppressants require more caution when you use them due to possible severe side effects and addiction potential. Long-term prescription appetite suppressants are generally safe if you take them as prescribed.