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The comparison between Ativan and Trazodone for the management of sleep disturbance illuminates the fundamental differences in the pharmacological approaches to insomnia and the clinical characteristics that guide the selection of one agent over the other for individual patients with specific patterns of sleep difficulty. The hyperalgesic effects of sleep deprivation have been demonstrated in controlled laboratory studies where healthy volunteers subjected to sleep restriction show increased sensitivity to painful stimuli and reduced tolerance for sustained pain, effects that are magnified in patients whose pain processing systems have already been sensitized by peripheral nerve injury. Trazodone 50mg Street Price New-age medicine. The prescribing of Hydrocodone in this context should be at the lowest effective dose, for the limited duration that the acute pain is expected to require opioid-level analgesia, and with the explicit instruction that the patient should not take the full prescribed dose of Trazodone concurrently with the Hydrocodone if the combination produces excessive sedation or if the patient has risk factors for respiratory depression.
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Indicated for: Major Depressive Disorder (MDD), Depressive Episodes, Unipolar Depression, Anxiety Disorder associated with Depression, Generalized Anxiety Disorder (GAD), Chronic Primary Insomnia, Secondary Insomnia (particularly with SSRI-induced sleep disturbance), Obstructive Sleep Apnea (as an adjunct to reduce arousal threshold), Painful Diabetic Neuropathy, Fibromyalgia Syndrome, Post-Traumatic Stress Disorder (PTSD) (off-label for sleep disturbances), Behavioral and Psychological Symptoms of Dementia (BPSD) (for agitation/sleep).
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